Indiana will face Ole Miss in the first round of the O'Reilly Auto Parts Puerto Rico Tip-Off on Nov. 19 in San Juan. Officials released the tournament's bracket Tuesday.
IU's first-round game will begin at 5 p.m. and air on ESPN2.
This will be the first meeting between the two teams. The Hoosiers hold a 52-34 edge over Southeastern Conference opponents and Ole Miss is the only SEC team the Hoosiers have not played.
"I know our players, coaches and fans look forward to competing on a national stage and are excited to get the opportunity to appear on national television," IU coach Tom Crean said in a statement released by the university. "This is an outstanding field to compete against and should present a tremendous challenge."
Indiana will play Kansas State or Boston University in the tournament semifinal or consolation round Nov. 20. The teams will have a day off Nov. 21 and then the championship game is scheduled for 8 p.m. Nov. 22 on ESPN2.
Nine of the 12 games in the event will appear on either ESPNU or ESPN2.
Dayton and Georgia Tech will open tournament play at 11:30 a.m. Nov. 19. Villanova and George Mason will compete in the other tournament quarterfinal at 2 p.m. Kansas State and Boston University will play at 7:30 p.m. Nov. 19.