It took Notre Dame nearly three quarters of the first half to establish some dominance against Eastern Michigan as the Irish limbed into halftime with a 35-27 lead.
Skylar Diggins started a run that gave Notre Dame some breathing room with 5:37 to play in the half with a coast-to-coast layup.
After Eastern Michigan's Tavelyn James answered with a jumper, Diggins sank a pair of free throws and scored on a second try after being blocked to give the Irish a 26-21 lead.
Notre Dame's Melissa Lechlitner and Brittany Mallory then hit back-to-back three-pointers, and Lechlitner hit 1 of 2 free throws to cap a 13-2 run that gave the Irish a 33-21 lead.
It was a sloppy first half with Notre Dame committing 11 turnovers and Eastern Michigan 12. The Irish shot 40 percent from the field, and the Eagles shot 32.4 percent.
Becca Bruszewski, who kept Notre Dame afloat for most of the first half, has 10 points, and James scored 10 for Eastern Michigan.