Notre Dame took a 41-28 lead over IPFW into halftime thanks to an aggressive defense in the first half.
The No. 3 Irish had 13 steals and forced 19 turnovers in the first half. Notre Dame scored 22 points off the turnovers.
The Irish started fast against the Mastodons, scoring six points in the first 90 seconds, applying foul-court pressure to start the game and picking up three steals in the opening four minutes.
But IPFW was able to stay with Notre Dame through most of the first half thanks to the three-point shooting of guard Anne Boese, who scored 14 in the half.
Boese hit 4 of 5 three-pointers in the first half. The Mastodons' first nine points came from behind the three-point arc as Boese sank her first two threes and Jordan Zuppe sank a three as the Mastodons trailed 12-9 with 13:37 to play.
IPFW took a short-lived 18-17 lead with 10:18 to play, but Notre Dame locked down on defense against and closed the half on a 24-10 run.
Becca Bruszewski scored 14 points in the half for the Irish, and Ashley Barlow added seven.
IPFW's Chelsey Jackson scored nine in the half.
IPFW will have to figure out a way to work through Notre Dame's ball pressure or things will get worse in the second half.
While the Mastodons were able to stay in the game for a while by hitting 6 or 12 three-pointers, they will need to penetrate the Irish's defense in the second half and get some points down low.
Notre Dame had 28 points in the paint compared to IPFW's 6 in the first half.