Notre Dame fell 69-68 to St. John's as Tory Jackson missed two three-pointers in the final two seconds in Purcell Pavilion.
Tim Abromaitis gave the Irish (17-9, 6-7 Big East) a 66-64 lead with 1:25 to play when he hit a three-pointer from the left corner.
Abromaitis' three came on the heels of his old-fashion three-point play when he sank a free-throw after getting fouled on a baseline dunk.
After St. John's took a 67-66 lead with a three with 57.8 seconds to play, Tyrone Nash did his best Luke Harangody impersonation.
Nash drew a foul on the left block and sank two free throws for a 68-67 lead with 38.9 to play. Harangody did not play Sunday because of a bruised bone on his right knee.
But St. John's (14-10, 4-8) took the lead back with a pair of free throws from D.J. Kennedy with 12.5 to play.