Notre Dame named the stadium its football team will play its off-site game for the 2011 season.
The Irish will take on Maryland in 91,704-seat FedEx Field, home of the Washington Redskins in Landover, Md., on Nov. 12, the university announced Monday.
The second meeting between the Irish and Terrapins will be the third in a series of off-site games that Notre Dame started playing last season with a 40-14 win over and Washington State on Oct. 30 at the Alamodome in San Antonio, Texas.
"As we have looked to move one game a season around the country, playing in the Washington, D.C., area seemed a natural for us in terms of institutional fit," Notre Dame athletic director Jack Swarbrick said in a statement.
"The size of the FedEx Field facility alone will provide great access to tickets for fans of both Notre Dame and Maryland and the opportunity to spend a weekend in our nation's capitol should be a tremendous attraction."
Notre Dame will play in Yankee Stadium this season when it takes on Army on Nov. 20, and the Irish are slated to play Arizona State in the Dallas Cowboys' stadium in Arlington, Texas, in 2013.
In Notre Dame's only game against Maryland, the Irish defeated the Terps 20-0 in 2002 at Giants Stadium.
The game against Maryland is expected to be televised in prime time by NBC, the university said.
Tickets for the game are expected to be made available to contributing alumni and fans through an alumni lottery as the school does with all other football games.