In last year's season opener, Indiana let Eastern Kentucky hang around in the first half, which made for a tight game in the end.
That doesn't appear to be the case in the 2010 opener against Towson.
The Hoosiers capitalized on two turnovers and lead 17-0 at the end of the first quarter.
Tyler Replogle and Mitchell Evans intercepted Chris Hart passes.
Replogle's pick led to a 12-yard touchdown pass from Ben Chappell to tight end Ted Bolser.
Evans, who played wide receiver and served as the quarterback in wildcat formations last season, intercepted a pass to end Towson's next possession. Two plays later, running back Darius Willis went 48 yards for a touchdown.
IU added a field goal late in the quarter to increases the lead to 17-0.