Ball State coach Stan Parrish said he was "very, very disappointed" with the way his team's running game played last week.
The Cardinals managed only 119 yards.
But Purdue coach Danny Hope still said his focus so far this week has been watching film on Ball State's running game.
When asked about the Cardinals' quarterback situation -- they likely will play two players -- Hope turned the conversation to the running game.
"They're really, really good at the power run game. They're exceptional at it," Hope said. "They've got some horses in the backfield. They have really good running backs. They're very physical runners, and they're fast, and their offensive line is athletic and has a really good tempo and motor about it."
Ball State ranks 36th out of 120 FBS schools in rushing through two games, averaging 194 per game. The opener was a victory over Southeast Missouri.
Purdue defensive end Ryan Kerrigan said he watched some film on Ball State on Monday and noticed that they ran the power offense almost every play.
Ball State has spread carries between three running backs through the first two weeks.
"It'll be a great test," Kerrigan said. "Having gone against Western Illinois last week, and they run a similar kind of style, that will help us out. I'm really excited to see how we respond to this power running game because in the past, we've been known as a defense that doesn't do so well against the power running game."