It didn't matter who the quarterback was for Miami, Notre Dame safety Harrison Smith was going to pick him off as the Irish took a 27-3 halftime lead.
The senior ended the Hurricanes' first three drives of the second quarter with interceptions, picking off starter Jacory Harris twice and backup Stephen Morris once.
Smith's three interceptions tied Shane Walton's school record for most in a game set in the 2002 Kickoff Classic against Maryland, and Smith matched Buddy McClinton's Sun Bowl interceptions record set in 1968.
Notre Dame made Miami pay for Jacory Harris' second interception early in the second quarter.
Cierre Wood broke off a 34-yard touchdown run to give the Irish a 21-0 lead with 13:21 to play in first half.
Notre Dame kicker David Ruffer stayed perfect for the season and his career when he hit two field goals in the second quarter.
Ruffer connected on a 40- and 50-yarder to improve to 17 for 17 on field-goal attempts this season and 22 for 22 for his career.
Miami finally scored when Matt Bosher connected on a 47-yard field goal as time expired in the first half.
Notre Dame has outgained Miami 231-166.
Irish quarterback Tommy Rees did limp off the field, favoring his left leg, after Notre Dame's final series. The freshman has thrown for 113 yards and two touchdowns.