E'Twaun Moore got hot -- making five three-pointers in the first six minutes -- and helped No. 12 Purdue surge to a 42-30 lead over Northwestern in Mackey Arena.
Moore scored 15 first-half points, and JaJuan Johnson has 12. But point guard Lewis Jackson scored six consecutive points in one stretch late in the half, helping the Boilermakers finish the half on a 9-0 run.
Northwestern didn't score a point in the final 5:07.
The Wildcats entered the game as one of the nation's top field-goal percentage teams, but the Boilermakers have held them to 38 percent in the first half.
Northwestern leading scorer John Shurna is 2 of 5 from the floor for five points. D.J. Byrd started the game on Shurna, and when Kelsey Barlow came off the bench, he defended Shurna. E'Twaun Moore has also switched to guard Shurna on a couple possessions.
Shurna scored on a drive with Barlow guarding him and made a three-pointer in Byrd's face on another possession.