Indiana took a 2-1 halftime lead Wednesday over Notre Dame at Parkview Field.
The Hoosiers' Blake Wise scored the leading goal in the 41st minute when he collected a loose ball about 35 yards out from Notre Dame's goal.
The freshman forward uncoiled a laser shot that went past Irish goalkeeper Will Walsh as he dove to his left to try to stop the shot.
Notre Dame opened the scoring at the 4-minute mark when midfielder Danny O'Leary was able to knock a crossing pass from the left wing by Brendan King past IU keeper Luis Soffner and a defender.
The Hoosiers answered the Irish's goal in the 9th minute when Harrison Petts drilled a crossing pass from the right wing by Alec Purdie inside the left goal post.
IU largely controlled the game's opening half.
The Hoosiers put seven shots on goal to the Irish's four, and IU was able to set up its offense more in Notre Dame's zone.
The Irish's scoring chances largely came on transition, and Adam Mena and Aaron Maud settled for shots from about 35 out during transition in a minute span of each other in the half's final 7 ½ minutes.