BOSTON – David Ortiz homered in Boston’s eight-run first inning, then got into a bench-clearing brawl with Baltimore reliever Kevin Gregg as the Red Sox routed the Orioles 10-3 on Friday night.

Ortiz and Gregg exchanged a flurry of punches in the eighth, but neither connected before they were separated as both benches and bullpens emptied for the second time in the inning.

Moments before the fight, Ortiz started toward the mound after taking a second straight pitch inside from Gregg. The benches and bullpens emptied, but nothing developed and Ortiz stepped back into the batter’s box.

Gregg got him to pop out, then shouted something as the Boston slugger started down the first-base line. Plate umpire Mike Estabrook immediately ejected Gregg – and Ortiz quickly changed course, charging toward the mound. Gregg and Ortiz each threw a few haymakers, but the heavyweight bout was swallowed up by the mass of players rushing onto the field.

It took more than 15 minutes to restore order and sort out the ejections. Gregg and Ortiz were tossed, as well as Red Sox catcher Jarrod Saltalamacchia and Baltimore reliever Jim Johnson.

Estabrook couldn’t quite reach Ortiz in time to stop him from getting to Gregg. The benches and bullpens cleared again as Boston fans cheered “Pa-pi! Pa-pi!”

The Orioles, who allowed 10 or more runs for the fourth time in five games, were flustered after the Red Sox sent 13 batters to the plate in the opening inning and tagged starter Zach Britton for seven earned runs on six hits and two walks. Ortiz hit a three-run shot.

It was Boston’s fourth straight win, and it extended Baltimore’s losing streak to five.

TIGERS 6, ROYALS 4: In Kansas City, Mo., Magglio Ordonez’s two-run home run just six pitches into the game staked Rick Porcello to an early lead and got Detroit rolling.

BLUE JAYS 11, INDIANS 7: Travis Snider drove in five runs, and Rajai Davis knocked in four as Toronto rebounded a day after a stunning loss to win in Cleveland.

Jo-Jo Reyes (4-7) pitched 5 2/3 shaky innings for his first win in his last four starts. He gave up three unearned runs, eight hits and two walks without a strikeout as Cleveland left 12 men on base and couldn’t build momentum off its exciting win Thursday night on Travis Hafner’s walk-off grand slam.

RANGERS 8, ATHLETICS 5: In Arlington, Texas, C.J. Wilson pitched seven effective innings, Mike Napoli hit a first-inning grand slam off Gio Gonzalez, and Texas stretched its winning streak to five games, a night after a fan fell to his death.

Josh Hamilton, who tossed the ball to the fan on Thursday night, hit a fan with a foul ball off his bat. The teenage male fan had blood on his face and was tended to by stadium personnel before he walked away, smiling while he held a compress to his head.

Rangers officials said the fan was treated at the stadium and was OK. They didn’t identify him or provide additional details.

YANKEES-RAYS, ppd., rain: New York’s home game with Tampa Bay was postponed because of rain, delaying Yankees shortstop Derek Jeter’s pursuit of 3,000 hits by a day. The game will be made up Sept. 22, although the Yankees wanted to make it up today. The Rays voted it down, the two teams agreed to Sept. 22, a scheduled day off for both.