Notre Dame entered halftime with a 21-3 lead over Purdue in Ross-Ade Stadium.
Irish running back Cierre Wood scored on a career-long run of 55 yards with 9:06 to play to help erase the memory of a second missed field goal by Notre Dame early in the quarter.
Notre Dame's special teams woes reared its ugly head early in the second quarter.
After the Irish's first drive of the quarter stalled at the Boilermakers' 32, David Ruffer attempted a 49-yard field goal died in the wind, leaving Notre Dame with a 14-0 lead with 10:20 play in the first half.
Before the field goal attempt, Purdue's Josh Johnson missed an easy interception after Tommy Rees threw over TJ Jones' head that could have been returned for a touchdown.
Purdue finally scored thanks to kicker Carson Wiggs' 27-yard field goal with 3:39 to play in the half.
Wiggs missed on a chance to add another 3 points with 8 seconds to play when his 54-yard field goal missed wide right.
Notre Dame holds a 316-122 advantage in yards as the Irish got through the first half without a turnover.
Michael Floyd added another school record during the second quarter when he grabbed a 14-yard reception to give him 112 yards for the game. The reception marked the 16th time Floyd had gone over 100 receiving yards to break a tie he held with Golden Tate.
Purdue cannot get its running game going, gaining only 32 yards in the first half, and the Boilermakers cannot stop the Irish's running backs.
Notre Dame has run for 158 yards with Wood leading the way with 102 yards and a TD. Jonas Gray has run for 55 yards with a TD.