Notre Dame may want to wait another 21 years before it plays a home night game.
The Irish fell behind USC 14-0 after the first quarter.
Notre Dame went three-and-out on its first two possessions after opening four of its last five games with opening scoring drives.
Worse for the Irish was letting an opponent score on its first drive all season and then letting it happen again.
USC marched 66 yards on 13 plays on its first drive to take a 7-0 lead with 6:16 to play in the first quarter after tight end Randall Telfer hauled in a 2-yard TD toss.
The Trojans gained 60 yards by running, and they chewed up 7:39 on the drive.
USC didn't take as long to score on its second drive, which lasted 2:47. The Trojans went 62 yards on six plays and Matt Barkley completed his second touchdown pass when he found receiver Robert Woods wide open in the back of the end zone on a 3-yard pass.
Woods' TD gave USC a 14-0 lead with 1:01 left in the first quarter.