Notre Dame will play Rice for the first time in 26 years in the 2014 season.
The Owls announced on their website that the programs will play in 2014 in Notre Dame Stadium. The time and date of the game will be announced at a later date.
The Irish have won the four previous matchups against Rice with the last game coming in 1988. Notre Dame won that game 54-11.
"Notre Dame is a program that shares our core beliefs about college athletics," Rice athletic director Rick Greenspan said on the school's athletic website. "We both believe that the pursuit of excellence in the classroom need not become secondary to the pursuit of championships in athletics. This type of schedule is reflective of the greater overall vision for the second century of Rice Athletics that we will begin share in the coming weeks.
"We are excited to add this game to the schedule in order to give our student-athletes and our fans this tremendous opportunity to experience a game day in South Bend and renew this series with the Irish."
Notre Dame first played Rice in 1915 with the Irish coming out with a 55-2 victory to close the season in Houston. The two teams played again in 1973 with Notre Dame winning 28-0 in Houston. The Irish also won a 1974 matchup in South Bend 10-3.
Rice joins a group of non-traditional opponents Notre Dame will face in 2014. The Irish will also play Northwestern, Syracuse and Temple that season.