Indiana leads Bryant 48-28 at halftime in the season opener Friday at Assembly Hall.
Cody Zeller has 12 points and five rebounds for the No. 1 Hoosiers. Kevin "Yogi" Ferrell has 10 points and five assists.
The Hoosiers are shooting 55.6 percent from the floor. Bryant is shooting 31.3 percent.
IU is outrebounding Bryant 24-16. Both teams have nine turnovers.
Bryant led 15-14 with 11:37 to go in the half. The Hoosiers then went on an 11-1 run.