Notre Dame opened Senior Day with by scoring multiple home games worth of points in the first quarter against Wake Forest.
The Irish jumped out to a 21-0 lead as quarterback Everett Golson completed 8 of 10 passes for 129 yards with touchdown throws to Dwenger graduates Tyler Eifert and John Goodman.
Notre Dame's 21 points in the first quarter were more than the Irish have scored in regulation games all season and one more point than the Irish's total in an overtime home win over Stanford.
Cierre Wood got things going for Notre Dame on its fourth play of the game as the senior took a pitch from Golson and sprinted 68 yards for a touchdown.
Wood's run was the longest play of the season for the Irish and gave them a 7-0 lead less than 2 minutes into the game.
The Irish quickly got the ball back when linebacker Carlo Calabrese demolished Wake Forest running back Josh Harris and jarred the ball loose and into safety Zeke Motta's hands at Notre Dame's 48.
Eight plays later and after a failed first attempt, Golson hit Eifert on a fade for a 2-yard touchdown and a 14-0 lead with 9:10 to play in the first.
Goodman scored the Irish's next touchdown as he came down with a 50-yard pass from Golson in the Demon Deacons' end zone for a 21-0 lead with 4:28 left in the first quarter. It was Goodman's third TD catch of the season and the first time the senior scored in Notre Dame Stadium.