SAN FRANCISCO – Colin Kaepernick tossed his first two career touchdown passes, Kendall Hunter ran for a score and the San Francisco 49ers beat the Chicago Bears 32-7 Monday night.

Kaepernick completed 16 of 23 passes for 243 yards and looked calm and in control in his first NFL start. With Alex Smith out with a concussion, Kaepernick threw touchdown passes to Vernon Davis and Michael Crabtree and engineered four straight scoring drives to pace San Francisco’s sizzling start.

The former Nevada quarterback turned the Battle of the Backups into a one-sided affair.

Jason Campbell also started for the Bears with Jay Cutler out with a concussion. Campbell completed 14 of 22 passes for 107 yards, including a touchdown to Brandon Marshall after San Francisco (7-2-1) sprinted to a 27-0 lead.

Campbell, who missed the final 10 games with the Oakland Raiders last season with a broken collarbone, also threw two interceptions while working under constant pressure. Aldon Smith sacked him four times alone as Chicago (7-3) struggled to get any offensive momentum until Marshall’s 13-yard TD catch late in the third quarter.

What a night for San Francisco’s 2011 draft class.

Smith (7th overall), Kaepernick (second round, 36th overall) and Hunter (fourth round, 115th overall) all made their mark on Monday Night Football.

Smith’s sacks gave him 13 1/2 on the season, passing Denver’s Von Miller (13) for the NFL lead. Hunter had three carries for 28 yards behind Frank Gore (14 carries for 64 yards) and Kaepernick kept the 49ers in rhythm.

In a matchup of two NFC division leaders, San Francisco seemed to have no problem with a late fill-in starter.

Late Monday morning, the 49ers announced Smith failed to pass final tests under the NFL’s concussion treatment protocol.