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  • Disability claims ease as the economy heals
    The number of U.S. workers filing long-term disability claims declined for the first time in at least four years in 2012 amid an improving economy and employment picture.
  • Changes to Medicare may increase savings, confusion to diabetics
    Medicare begins a major change next month that could save older diabetics money and time when they buy crucial supplies to test their blood sugar – but it also may cause some confusion as patients figure out the new system.
  • Autism linked to air pollution, brain wiring
    Researchers seeking the roots of autism have linked the disorder to chemicals in air pollution and, in a separate study, found that language difficulties of the disorder may be due to a problem in brain wiring.
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Patients’ own cells spur cancer remission

Nine leukemia patients are cancer-free after being treated with genetically-altered versions of their own immune cells, giving strength to a promising new approach for treating the blood cancer.

The trial of 12 patients, two of them children, bolsters findings from 2011. Then, scientists from the University of Pennsylvania in Philadelphia reported that two of the first three patients treated showed no traces of the malignancy after getting the therapy.

The results were presented Sunday at the American Society of Hematology’s annual meeting in Atlanta.

For Walter Keller, 59, who had failed every other treatment for his chronic lymphocytic leukemia diagnosed in 1996, the regimen meant he’s been in remission since his treatment in April. Before the therapy, “I thought I had a year to live,” he said.

“I feel better than I have in a long, long time,” said Keller, of Upland, Calif., in a telephone interview. “I’m excited because I think this will help a lot of people.”

The approach developed by University of Pennsylvania scientists has since been acquired by Novartis.

The scientists, led by Carl June, a professor of pathology and laboratory medicine at the Abramson Cancer Center at the University of Pennsylvania and a study author, used genetic engineering to manipulate white blood cells extracted from the patients.

The researchers reprogrammed the cells to specifically target the leukemia cells and reinjected them into the patients.

CLL is a slow-growing cancer that starts from white blood cells in the bone marrow and interferes with the production of healthy blood cells. The condition leads to complications such as immune deficiencies and swollen lymph nodes. The disease strikes about 16,000 adults each year and 4,600 die from it, according to the American Cancer Society.

The disease is treated with chemotherapy. Another approach is bone marrow transplant in which chemotherapy is first given to kill diseased cells then replaced with healthy ones from bone marrow.

The research was funded by the Leukemia & Lymphoma Society, the Alliance for Cancer Gene Therapy and the National Institutes of Health.

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