Deshaun Watson, Texans, was 25 for 34 for 283 yards with four touchdown passes and an interception in Houston's 57-14 win over Tennessee.
Andy Dalton, Bengals, was 25 for 30 for 286 yards and four touchdown passes in Cincinnati's 31-7 win over Cleveland.
Jameis Winston, Buccaneers, was 22 for 38 for 332 yards and three touchdowns in Tampa Bay's 25-23 win over the New York Giants.
Philip Rivers, Chargers, was 22 for 38 for 347 yards and two touchdowns in LA's 26-24 loss to Philadelphia.
Dak Prescott, Cowboys, was 20 for 36 yards for 252 yards and three touchdowns and an interception in Dallas' 35-30 loss to the Los Angeles Rams.
Tom Brady, Patriots, was 32 for 45 for 307 yards and two touchdowns in the Patriots' 33-30 loss to Carolina.
Drew Brees, Saints, was 29 for 41 for 268 yards and two touchdowns in New Orleans' 20-0 win over Miami.
Eli Manning, Giants, was 30 for 49 for 288 yards and two touchdowns.
Le'Veon Bell, Steelers, had 35 carries for 144 yards and two touchdowns in Pittsburgh's 26-9 win over Baltimore.
Bilal Powell and Elijah McGuire, Jets. Powell had 21 carries for 168 yards, including a 75-yard touchdown, and McGuire had 10 carries for 93 yards, including a 69-yard touchdown, in New York's 23-20 overtime victory over Jacksonville.
Todd Gurley, Rams, had 23 carries for 121 yards and added seven receptions for 94 yards and a touchdown.
LeGarrette Blount, Eagles, had 16 carries for 136 yards.
Keenan Allen and Tyrell Williams, Chargers. Allen had five catches for 138 yards and Williams added five receptions for 115 yards and a touchdown.
DeAndre Hopkins, Texans, had 10 receptions for 107 yards and a touchdown.
Charles Clay, Bills, had five receptions for 112 yards in Buffalo's 23-17 win over Atlanta.
Jaron Brown, Cardinals, had eight catches for 105 yards in Arizona's 18-15 overtime win over San Francisco.
Kelvin Benjamin, Panthers, had four receptions for 104 yards.
Greg Zuerlein, Rams, set a career high with seven field goals and added two extra points.
Robbie Gould, 49ers, was 5 for 5 on field goals.
Jake Elliott, Eagles, was 4 for 4 on field goals and added two extra points.
Phil Dawson, Cardinals, was 4 for 4 on field goals.
Myles Jack and Yannick Ngakoue, Jaguars. Jack returned a fumble 81 yards for a touchdown and Ngakoue had two sacks and a forced fumble.
Tre'Davious White, Bills, returned a fumble 52 yards for a touchdown.
Dylan Cole, Texans, returned an interception 25 yards for a touchdown.
– Associated Press