Carson Wentz, Eagles, tossed four touchdown passes to give him an NFL-leading 23, in Philadelphia's 51-23 rout of the Denver Broncos.
Kirk Cousins, Washington, drove 70 yards in 35 seconds, capped by Rob Kelley's 1-yard touchdown run with less than a minute remaining to stun the Seattle Seahawks 17-14.
Jacoby Brissett, Colts, threw for 308 yards and two touchdowns in Indianapolis' 20-14 win at Houston.
Drew Brees, Saints, completed 81.2 percent of his passes (22 of 27) for 263 yards and two touchdowns in New Orleans' 30-10 victory over Tampa Bay.
Adrian Peterson, Cardinals, carried a career-high 37 times for 159 yards in Arizona's 20-10 victory over winless San Francisco.
Ezekiel Elliott, Cowboys, ran for 93 yards and a TD on 27 carries in Dallas' 28-17 win over Kansas City.
Jay Ajayi, Eagles, had 77 yards rushing and one score – a 46-yarder – in his Philadelphia debut.
Todd Gurley, Rams, ran for two touchdowns in Los Angeles' 51-17 win over the New York Giants.
Corey Clement, Eagles, rushed for two scores and also caught a TD pass.
Rob Kelley, Washington, had two TD runs.
T.Y. Hilton, Colts, had 175 yards receiving with two touchdowns.
Alshon Jeffery, Eagles, had touchdown catches of 32 and 4 yards.
Marqise Lee, Jaguars, had eight receptions for 75 yards and a TD in Jacksonville's 23-7 victory over Cincinnati.
Robert Woods, Rams, caught two touchdown passes.
Alvin Kamara, Saints, had six catches for 84 yards, including a 36-yard TD, and also scored on a 6-yard run.
Terrence Williams, Cowboys, caught a career-best nine passes for 141 yards.
Justin Hardee, Saints, blocked Bryan Anger's punt and returned it seven yards for a touchdown.
Jaydon Mickens, Jaguars, returned a punt 63 yards for a score in the fourth quarter.
Greg Zuerlein, Rams, booted three field goals and made all six of his extra points.
Jabaal Sheard, Colts, had two sacks – his second of the game forced fumble as time ran out.
Kevin Byard, Titans, intercepted two passes in Tennessee's 23-20 win over Baltimore, giving him five over his past two games.
Keanu Neal, Falcons, forced two fumbles by Jonathan Stewart and recovered one in Atlanta's 20-17 loss to Carolina.
Brandon Marshall, Broncos, returned a fumble 19 yards for a TD.
Dwight Freeney, Seahawks, had two sacks, giving him three in the two games since joining the team.
– Associated Press