Jared Goff, Rams, passed for 424 yards and two touchdowns, leading Los Angeles to a 34-7 win over Arizona.
Aaron Rodgers, Packers, threw four touchdown passes in the snow and Green Bay rebounded from an embarrassing 29-point loss to San Francisco and beat the New York Giants 31-13.
Ryan Fitzpatrick, Dolphins, was 27 for 39 for 365 yards and three touchdowns as Miami achieved season highs in points and yards (408) in a 37-31 victory over Philadelphia.
Drew Lock, Broncos, had two touchdown passes in his NFL debut, a 23-20 victory over the Los Angeles Chargers.
Raheem Mostert, 49ers, ran for a career-high 146 yards and a touchdown.
Derrick Henry, Titans, had 26 carries for 149 yards and scored on a 13-yard TD run on fourth down to cut the deficit to 17-14 in the third quarter, and Tennessee went on to beat Indianapolis 31-17.
Derrius Guice, Washington, racked up 129 yards and two touchdowns, helping Washington to a 29-21 victory over Carolina.
Robert Woods, Rams, had 13 catches for 172.
Davante Adams, Packers, caught two touchdown passes.
James Washington, Steelers, finished with 111 yards receiving and a touchdown on four catches to help Pittsburgh top Cleveland 20-13.
Courtland Sutton, Broncos, had two TD receptions.
Jason Sanders and Matt Haack, Dolphins. Sanders caught a 1-yard touchdown pass on a fluttery throw by Haack when Miami opted to not go for a field goal on fourth down and instead scored on the trick play. Sanders became the first kicker with a TD catch since Denver's Jim Turner in 1977.
Justin Tucker, Ravens, kicked a 49-yard field goal as time expired.
Brandon McManus, Broncos, booted a 53-yard field goal as time expired, set up by a long interference call.
Dane Cruikshank and Tye Smith, Titans. Cruikshank raced through an inside gap to block a potential tiebreaking field goal late in the fourth quarter and Smith returned it 63 yards for the go-ahead touchdown.
Devin White, Buccaneers, scooped up a fumble and returned it 14 yards for a touchdown, and also had an interception in Tampa Bay's 28-11 victory at Jacksonville.
Juan Thornhill, Chiefs, returned an interception 46 yards for a score.
Carlos Dunlap, Bengals, had three sacks in Cincinnati's 22-6 win over the New York Jets.
Taylor Rapp, Rams, returned an interception 31 yards for a touchdown.